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531399 IRE1 Inhibitor IV, A-106

A cell permeable compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1).

IRE1 Inhibitor IV, A-106 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ERN1 Inhibitor, A106

Primary Target: IRE1
531399
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₁H₈O₂
Description
Overview

This product has been discontinued.



A cell permeable naphthaldehyde based compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1). Shown to be equipotent to its parent compound, STF-083010. Blocks IRE-1 RNase activity via the formation of a stable Schiff base with K907 in the RNase domain of IRE-1, which prevents splicing of XBP-1mRNA. Downregulation of XBP-1 in Em-TCL1 CLL cells leads to apoptosis (~50 to 100 µM). Blocks the proliferation and survival of patient-derived pre-B ALL cells (10 to 50 thousand cells) in sub-lethally irradiated NOD/SCID mice in a dose-dependent manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531399
Brand Family Calbiochem®
SynonymsERN1 Inhibitor, A106
References
ReferencesKriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.
Product Information
FormYellowish-white powder
Hill FormulaC₁₁H₈O₂
Chemical formulaC₁₁H₈O₂
Quality LevelMQ100
Applications
Biological Information
Primary TargetIRE1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531399 0

Documentation

IRE1 Inhibitor IV, A-106 MSDS

Title

Safety Data Sheet (SDS) 

IRE1 Inhibitor IV, A-106 Certificates of Analysis

TitleLot Number
531399

References

Reference overview
Kriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.