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GF337 IL-4,
Human Recombinant Animal Free

IL-4,
Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P05112
GF337
20µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF337
DescriptionIL-4,
Human Recombinant Animal Free
Alternate Names
  • Interleukin-4
  • IL4
Background InformationIL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naïve CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy.
Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
References
Product Information
PresentationProduct is presented without additives and is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceProtein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceDetermined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size20µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF337 04053252979385

Documentation

IL-4,
Human Recombinant Animal Free MSDS

Title

Safety Data Sheet (SDS) 

IL-4,
Human Recombinant Animal Free Certificates of Analysis

TitleLot Number
IL-4, Human Recombinant Animal Free - Q2445317 Q2445317
IL-4, -2799057 2799057
IL-4, Human Recombinant Animal Free - 3062245 3062245
IL-4, Human Recombinant Animal Free - 3290402 3290402
IL-4, Human Recombinant Animal Free - 3389897 3389897
IL-4, Human Recombinant Animal Free - 3446264 3446264
IL-4, Human Recombinant Animal Free - 3549787 3549787
IL-4, Human Recombinant Animal Free - 3671735 3671735
IL-4, Human Recombinant Animal Free - 3782173 3782173
IL-4, Human Recombinant Animal Free - 3837030 3837030
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