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401493 IKK Inhibitor XIII, 17-AJB - Calbiochem

The IKK Inhibitor XIII, 17-AJB controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

IKK Inhibitor XIII, 17-AJB - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
401493
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₂₈O₆
Description
Overview

This product has been discontinued.



A cell-permeable herbal-derived jolkinolide that acts as an irreversible inhibitor against IKK-β activity (IC50 = 300 nM). 17-AJB at 10 µM is shown to completely suppress TNF-α-induced IκB-α phosphosphorylation/degradation and NF-κB transcription activity in HepG2 cultures, as well as NF-κB p65 nuclear translocation in A549 cells. Reported to inhibit the growth of several cancer cell lines, including U937, Jurkat, and CoLo205 (IC50 = 0.74, 1.06, and 2.34 µM, respectively).
Catalogue Number401493
Brand Family Calbiochem®
References
ReferencesYan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.
Product Information
FormOff white solid
Hill FormulaC₂₂H₂₈O₆
Chemical formulaC₂₂H₂₈O₆
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
401493 0

Documentation

IKK Inhibitor XIII, 17-AJB - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

IKK Inhibitor XIII, 17-AJB - Calbiochem Certificates of Analysis

TitleLot Number
401493

References

Reference overview
Yan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-August-2010 RFH
DescriptionA cell-permeable herbal-derived jolkinolide that acts as an irreversible inhibitor against IKK-β activity (IC50 = 300 nM). 17-AJB at 10 µM is shown to completely suppress TNF-α-induced IκB-α phosphosphorylation/degradation and NF-κB transcription activity in HepG2 cultures, as well as NF-κB p65 nuclear translocation in A549 cells. Reported to inhibit the growth of several cancer cell lines, including U937, Jurkat, and CoLo205 (ICsub>50 = 0.74, 1.06, and 2.34 µM, respectively).
FormOff white solid
Chemical formulaC₂₂H₂₈O₆
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYan, S., et al. 2008. Mol. Cancer Ther. 7, 1523.