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GF323 IGF-II, Human Recombinant
Animal Free

IGF-II, Human Recombinant
Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01344
GF323
50µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF323
DescriptionIGF-II, Human Recombinant
Animal Free
Alternate Names
  • Insulin-like Growth Factor-II
Background InformationThe IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGFII/ Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
References
Product Information
PresentationProduct is sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceProtein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceDetermined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥5 x 10^5 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size50µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF323 04053252979637

Documentation

IGF-II, Human Recombinant
Animal Free MSDS

Title

Safety Data Sheet (SDS) 

IGF-II, Human Recombinant
Animal Free Certificates of Analysis

TitleLot Number
IGF-II, Human Recombinant Animal Free - Q2441381 Q2441381
IGF-II, Human Recombinant -2783083 2783083
IGF-II, Human Recombinant Animal Free - 3946432 3946432
IGF-II, Human Recombinant Animal Free - 4086917 4086917
IGF-II, Human Recombinant Animal Free - 4212317 4212317
IGF-II, Human Recombinant, Animal Free, Recombinant Protein 2833497

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