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382149 Histone Deacetylase Inhibitor III

The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Histone Deacetylase Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide

Primary Target: Rat liver HDAC
382149
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
251456-60-7C₁₆H₂₅N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
382149-1MG Plastová ampulka 1 mg
Description
OverviewA cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
Catalogue Number382149
Brand Family Calbiochem®
SynonymsM344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
References
ReferencesRamiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
Jung, M., et al. 1999. J. Med. Chem. 42, 4669.
Product Information
CAS number251456-60-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₂₅N₃O₃
Chemical formulaC₁₆H₂₅N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRat liver HDAC
Primary Target IC<sub>50</sub>40 nM for rat liver HDAC
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
382149-1MG 04055977213164

Documentation

Histone Deacetylase Inhibitor III MSDS

Title

Safety Data Sheet (SDS) 

Histone Deacetylase Inhibitor III Certificates of Analysis

TitleLot Number
382149

References

Reference overview
Ramiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
Jung, M., et al. 1999. J. Med. Chem. 42, 4669.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsM344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
DescriptionA cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number251456-60-7
Chemical formulaC₁₆H₂₅N₃O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRamiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753.
Jung, M., et al. 1999. J. Med. Chem. 42, 4669.