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534034 Heterochromatin Inhibitor, HMS-I1 - Calbiochem

A cell-permeable, reversible inhibitor of heterochromatin-mediated gene silencing in mammalian, plant, and fungal cells (5 - 10 µM).

Heterochromatin Inhibitor, HMS-I1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1

Primary Target: Clr3-containing Snf2/HDAC repressor complex (SHREC)
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₁₄N₂O₂
Description
Overview

This product has been discontinued.



A cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
Catalogue Number534034
Brand Family Calbiochem®
Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
DescriptionHeterochromatin Inhibitor, HMS-I1
References
ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
Product Information
FormPale yellow solid
Hill FormulaC₁₆H₁₄N₂O₂
Chemical formulaC₁₆H₁₄N₂O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetClr3-containing Snf2/HDAC repressor complex (SHREC)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
534034 0

Documentation

Heterochromatin Inhibitor, HMS-I1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Castonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2016 JSW
Synonyms2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, 2-(2,3-Dihydro-1,4-benzo[b][1,4]dioxin-6-yl)-6-methylimidazo[1,2-a]pyridine, Heterochromatin Mediated Silencing Inhibitor 1
DescriptionA cell-permeable imidazopyridine based compound that lacks canonical zinc chelating moieties and acts in a reversible manner to disrupt heterochromatin-mediated transcriptional gene silencing in mammalian, fungal, and plant cells (5 - 10 µM). Targets Clr3-containing Snf2/HDAC repressor complex (SHREC) and inhibits HDAC6 and HDAC10 activities. Increases G418 resistance of cen1-kanMX cells. Shown to diminish H3K9 methylation and increase H3K9 and H3K14 acetylation in cells grown in the presence of G418. Murine erythroleukemia (MEL) cells grown in the presence of this compound can overcome α-satellite repeats-mediated gene silencing.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₁₄N₂O₂
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCastonguay, E., et al. 2015. Mol. Cell. Biol. 35, 662.