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400089 HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

The HIF-1α/2α Inhibitor IV, FM19G11, also referenced under CAS 329932-55-0, controls the biological activity of HIF-1α/2α. This small molecule/inhibitor is primarily used for Cell Structure applications.

HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV

400089
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
329932-55-0C₂₃H₁₇N₃O₈
Description
Overview

This product has been discontinued.



A cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 hours with 500 nM FM19G11.
Catalogue Number400089
Brand Family Calbiochem®
Synonyms2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV
References
ReferencesMoreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.
Product Information
CAS number329932-55-0
FormPale amber solid
Hill FormulaC₂₃H₁₇N₃O₈
Chemical formulaC₂₃H₁₇N₃O₈
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUse only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400089 0

Documentation

HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem Certificates of Analysis

TitleLot Number
400089

References

Reference overview
Moreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV
DescriptionA cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 h with 500 nM FM19G11.
FormPale amber solid
Intert gas (Yes/No) Packaged under inert gas
CAS number329932-55-0
Chemical formulaC₂₃H₁₇N₃O₈
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsUse only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMoreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.