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345883 GGTI-298 - CAS 180977-44-0 - Calbiochem

A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.

GGTI-298 - CAS 180977-44-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA

Primary Target: Rap1a
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
180977-44-0C₂7H₃3N₃O₃S
Description
OverviewA cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 µM) but has no effect on the processing of H-Ras even at concentrations of 15 µM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.
Catalogue Number345883
Brand Family Calbiochem®
SynonymsN-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
References
ReferencesQian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293.
Finder, J.D., et al. 1997. J. Biol. Chem. 272, 13484.
Miquel, K., et al. 1997. Cancer Res. 57, 1846.
Vogt, A., et al. 1997. J. Biol. Chem. 272, 27224.
McGuire, T., et al. 1996. J. Biol. Chem. 271, 27402.
Vogt, A., et al. 1996. Oncogene 13, 1991.
Product Information
CAS number180977-44-0
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂7H₃3N₃O₃S
Chemical formulaC₂7H₃3N₃O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRap1a
Primary Target IC<sub>50</sub>3 µM against processing of Rap 1A
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
345883 0

Documentation

GGTI-298 - CAS 180977-44-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

GGTI-298 - CAS 180977-44-0 - Calbiochem Certificates of Analysis

TitleLot Number
345883

References

Reference overview
Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293.
Finder, J.D., et al. 1997. J. Biol. Chem. 272, 13484.
Miquel, K., et al. 1997. Cancer Res. 57, 1846.
Vogt, A., et al. 1997. J. Biol. Chem. 272, 27224.
McGuire, T., et al. 1996. J. Biol. Chem. 271, 27402.
Vogt, A., et al. 1996. Oncogene 13, 1991.

Citations

Title
  • Niels W.C.J. van de Donk, et al. (2005) Geranylgeranylated proteins are involved in the regulation of myeloma cell growth. Clinical Cancer Research 11, 429-439.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision10-December-2012 JSW
    SynonymsN-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
    DescriptionA cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 µM) but had no effect on the processing of H-Ras even at concentrations of 15 µM. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis and enhances nitric oxide synthase-2 induction by IL-1β.
    FormWhite solid
    FormulationSupplied as a trifluoroacetate salt.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number180977-44-0
    Chemical formulaC₂7H₃3N₃O₃S
    Structure formulaStructure formula
    Purity≥90% by HPLC
    SolubilityDMSO (5 mg/ml). Degas DMSO just prior to reconstitution.
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
    Toxicity Standard Handling
    ReferencesQian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293.
    Finder, J.D., et al. 1997. J. Biol. Chem. 272, 13484.
    Miquel, K., et al. 1997. Cancer Res. 57, 1846.
    Vogt, A., et al. 1997. J. Biol. Chem. 272, 27224.
    McGuire, T., et al. 1996. J. Biol. Chem. 271, 27402.
    Vogt, A., et al. 1996. Oncogene 13, 1991.
    Citation
  • Niels W.C.J. van de Donk, et al. (2005) Geranylgeranylated proteins are involved in the regulation of myeloma cell growth. Clinical Cancer Research 11, 429-439.
    		•