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533259 FOXM1 Inhibitor III, FDI-6 - CAS 313380-27-7 - Calbiochem

FOXM1 inhibitor FDI-6; NCGC00099374

FOXM1 Inhibitor III, FDI-6 - CAS 313380-27-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FDI6, Forkhead Domain Inhibitory Compound 6, NCGC00099374

Primary Target: FOXM1
533259
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Overview

Key Spec Table

CAS #Empirical Formula
313380-27-7C₁₉H₁₁F₄N₃OS₂

Products

Catalogue NumberPackaging Qty/Pack
5.33259.0001 Sklená flaša 10 mg
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Description
Overview A cell-permeable thienopyridinylcarboxamide compound that selectively and directly binds to forkhead box M1 (FOXM1) in a 1:1 stoichiometry and reversibly blocks its DNA binding activity (IC50 = 22.5 µM). Does not affect the transcriptional activity of FOXA1, FOXA2, FOXP2, and GATA1 in any significant manner. Shown to suppress the expression of FOXM1 target genes and block the proliferation of FOXM1 expressing breast cancer cells (GI50 = 18 µM for MCF-7 and MDA-MB-231 cells and 21.8 µM for PEO-1 cells). Unlike thiostrepton (Cat. No. 598226), it displays minimal off-target effects and does not affect 20S proteasomal activity.
Catalogue Number533259
Brand Family Calbiochem®
SynonymsFDI6, Forkhead Domain Inhibitory Compound 6, NCGC00099374
References
ReferencesGormally , M.V., et al. 2014. Nat. Commun. 5, 5156.
Product Information
CAS number313380-27-7
FormYellow solid
Hill FormulaC₁₉H₁₁F₄N₃OS₂
Chemical formulaC₁₉H₁₁F₄N₃OS₂
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetFOXM1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.33259.0001 04055977281514