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504539 Eliprodil - CAS 119431-25-3 - Calbiochem

Eliprodil - CAS 119431-25-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX

Primary Target: NMDA receptors
504539
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
119431-25-3C₂₀H₂₃ClFNO

Products

Catalogue NumberPackaging Qty/Pack
5.04539.0001 Sklená flaša 10 mg
Description
OverviewA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, >100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for α1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain α receptors. Blocks neuronal voltage-gated Ca2+
Catalogue Number504539
Brand Family Calbiochem®
Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
References
ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
Product Information
CAS number119431-25-3
FormWhite solid
Hill FormulaC₂₀H₂₃ClFNO
Chemical formulaC₂₀H₂₃ClFNO
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>1, > 100, and > 100 →M for NR2B, NR2A, and NR2C, respectively.
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.04539.0001 04055977244878

Documentation

Eliprodil - CAS 119431-25-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Lengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
DescriptionA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, > 100, and > 100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for ς1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain ς receptors. Blocks neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). A neuroprotective agent in acute ischemic stroke. Prolongs the QT interval in EKG.
FormWhite solid
CAS number119431-25-3
Chemical formulaC₂₀H₂₃ClFNO
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (17 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.