330005 Sigma-AldrichEST - CAS 88321-09-9 - Calbiochem
A cell-permeable, irreversible inhibitor of cysteine proteases.
More>> A cell-permeable, irreversible inhibitor of cysteine proteases. Less<<EST - CAS 88321-09-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 88321-09-9 | C₁₇H₃₀N₂O₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 330005-1MG | Plastová ampulka | 1 mg |
| Description | |
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| Overview | A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. |
| Catalogue Number | 330005 |
| Brand Family | Calbiochem® |
| Synonyms | Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d |
| Product Information | |
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| CAS number | 88321-09-9 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₇H₃₀N₂O₅ |
| Chemical formula | C₁₇H₃₀N₂O₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | calpain-1 |
| Primary Target IC<sub>50</sub> | 10-100 µM for calpain-1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | RR0404300 |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 330005-1MG | 04055977195699 |
Documentation
EST - CAS 88321-09-9 - Calbiochem MSDS
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EST - CAS 88321-09-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 330005 |
References
| Reference overview |
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| Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129. Mehdi, S. 1991. Trends Biochem. Sci. 16, 150. McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432. Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678. Komatsu, K., et al. 1986. Exp. Neurol. 91, 23. Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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