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211274 (E)-Capsaicin

(E)-Capsaicin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Primary Target: NF-κB
211274
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
404-86-4C₁₈H₂₇NO₃
Description
Overview

This product has been discontinued.



We are offering Capsaicin (Cat. No. 211275)as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






An active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced responses in rat PC12 cells. Exhibits anti-nociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
Catalogue Number211274
Brand Family Calbiochem®
Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
References
ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
Pernow, B., et al. 1985. J. Immunol. 135, 8125.
Product Information
CAS number404-86-4
FormWhite solid
Hill FormulaC₁₈H₂₇NO₃
Chemical formulaC₁₈H₂₇NO₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetNF-κB
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRA8530000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
211274 0

Documentation

(E)-Capsaicin Certificates of Analysis

TitleLot Number
211274

References

Reference overview
Singh, S., et al. 1996. J. Immunol. 157, 4412.
Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
Pernow, B., et al. 1985. J. Immunol. 135, 8125.

Citations

Title
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-April-2008 RFH
    Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
    DescriptionAn active constituent of cayenne pepper. Has excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced respones in rat pheochromocytoma cells. Exhibits antinociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
    FormWhite solid
    CAS number404-86-4
    RTECSRA8530000
    Chemical formulaC₁₈H₂₇NO₃
    Structure formulaStructure formula
    Purity≥98% by TLC
    SolubilityEthanol (5 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Toxic
    Merck USA index14, 1768
    ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
    Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
    Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
    Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
    Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
    Pernow, B., et al. 1985. J. Immunol. 135, 8125.
    Citation
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•