662141 Sigma-AldrichDUB Inhibitor V, PR-619 - Calbiochem
DUB Inhibitor V, PR-619, CAS 21645-32-1, is a cell-permeable, broad-spectrum DUB inhibitor whose (C50 = 5-20 M).
More>> DUB Inhibitor V, PR-619, CAS 21645-32-1, is a cell-permeable, broad-spectrum DUB inhibitor whose (C50 = 5-20 M). Less<<DUB Inhibitor V, PR-619 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: PR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₇H₅N₅S₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 662141-25MG | Sklená flaša | 25 mg |
| Description | |
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| Overview | A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K48-linked, while PR619 treatment results in upregulation of both K48- and K63-linked polyUb chains. |
| Catalogue Number | 662141 |
| Brand Family | Calbiochem® |
| Synonyms | PR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine |
| References | |
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| References | Altun, M., et al. 2011. Chem. Biol. 18, 1401. Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165. |
| Product Information | |
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| Form | Light beige to yellow solid |
| Hill Formula | C₇H₅N₅S₂ |
| Chemical formula | C₇H₅N₅S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | DUB Inhibitor V, PR-619, CAS 21645-32-1, is a cell-permeable, broad-spectrum DUB inhibitor whose (C50 = 5-20 M). |
| Biological Information | |
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| Purity | ≥99% by HPLC |
| Physicochemical Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 662141-25MG | 04055977261240 |
Documentation
DUB Inhibitor V, PR-619 - Calbiochem MSDS
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DUB Inhibitor V, PR-619 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 662141 |
References
| Reference overview |
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| Altun, M., et al. 2011. Chem. Biol. 18, 1401. Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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