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239783 Cyclooxygenase Inhibitor Set - Calbiochem

The Cyclooxygenase Inhibitor Set controls the biological activity of Cyclooxygenase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Cyclooxygenase Inhibitor Set - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: COX-1
239783
  
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Overview

Replacement Information
Description
OverviewContains 100 mg of Meloxicam (Cat. No. 444800), 5 mg of NS-398 (Cat. No. 349254), 5 mg of SC-560 (Cat. No. 565610), and 5 mg of Sulindac Sulfide (Cat. No. 574102).
Catalogue Number239783
Brand Family Calbiochem®
References
ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.
Product Information
FormSolid
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Secondary targetCOX-2
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-42/43-63

Harmful if swallowed.
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
239783 0

Documentation

Cyclooxygenase Inhibitor Set - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Cyclooxygenase Inhibitor Set - Calbiochem Certificates of Analysis

TitleLot Number
239783

References

Reference overview
Fournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2007 RFH
DescriptionCyclooxygenases (COX) act on arachidonic acid to generate prostaglandins. They exist either as COX-1 or COX-2. COX-1, a constitutive enzyme associated with the endoplasmic reticulum, is responsible for maintaining normal physiologic function. It is found throughout the body, especially in the GI tract, kidneys, and platelets and its inhibition by NSAID is reported to cause GI damage, renal dysfunction, and platelet abnormalities. COX-2 is an inducible enzyme that is mainly associated with the nuclear envelope. It's activity is induced by several growth factors, cytokines, and inflammatory signals. COX-2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX-1 levels remain unchanged. Based on structural differences in the active sites of these isozymes, a new drug has been developed that specifically inhibits only the COX-2 activity. COX-2 inhibitors have the potential to provide the traditional benefits of NSAID with significantly reduced incidence of endoscopic ulcers. Hence, they offer greater therapeutic promise in the treatment of inflammation and cancer. This inhibitor set provides 4 inhibitors for testing the inhibitory effects on COX-1 and COX-2.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Multiple Toxicity Values, refer to MSDS
ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.