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217697 Cdk1 Inhibitor III

The Cdk1 Inhibitor III, also referenced under CAS 440362-74-3, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Cdk1 Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ethyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate

Primary Target: Cdk1/cyclin B
217697
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
440362-74-3C₂₀H₁₅NO₄
Description
Overview

This product has been discontinued.



A cell-permeable 1-aza-9-oxafluorene compound that acts as a highly selective Cdk1/cyclin B inhibitor (IC50 = 28.8 µM) with very little activity against Cdk5/p25, Cdk2/E, or Cdk4/D1. Unlike other Cdk inhibitors, it exhibits potent inhibitory effect against P-glycoprotein-mediated MDR (multidrug resistance) in cancer cells (~9-fold more potent than verapamil). Its special bifunctional cytostatic property makes it an excellent tool for research in cancer treatment.
Catalogue Number217697
Brand Family Calbiochem®
SynonymsEthyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate
References
ReferencesBrachwitz, K., et al. 2003. J. Med. Chem. 46, 876.
Product Information
CAS number440362-74-3
FormBrown powder
Hill FormulaC₂₀H₁₅NO₄
Chemical formulaC₂₀H₁₅NO₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCdk1/cyclin B
Primary Target IC<sub>50</sub>28.8 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
217697 0

Documentation

Cdk1 Inhibitor III MSDS

Title

Safety Data Sheet (SDS) 

Cdk1 Inhibitor III Certificates of Analysis

TitleLot Number
217697

References

Reference overview
Brachwitz, K., et al. 2003. J. Med. Chem. 46, 876.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsEthyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate
DescriptionA cell-permeable, highly selective Cdk1/cyclin B inhibitor (IC50 = 28.8 µM). Exhibits only low inhibitory activity against Cdk5/p25, Cdk2/cyclin E, and Cdk4/cyclin D1. Unlike other Cdk inhibitors has also been reported to have potent inhibitory effects on P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells (~9-fold more potent than verapamil). Its unique bifunctional cytostatic properties make it an attractive tool in cancer research.
FormBrown powder
Intert gas (Yes/No) Packaged under inert gas
CAS number440362-74-3
Chemical formulaC₂₀H₁₅NO₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBrachwitz, K., et al. 2003. J. Med. Chem. 46, 876.