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219379 Cathepsin K Inhibitor II - Calbiochem

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Cathepsin K Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc

Primary Target: cathepsin K
219379
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₅H₅₁N₇O₈

Products

Catalogue NumberPackaging Qty/Pack
219379-1MG Plastová ampulka 1 mg
Description
OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
Catalogue Number219379
Brand Family Calbiochem®
SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
References
ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
Product Information
ATP CompetitiveN
FormLyophilized white solid
Hill FormulaC₃₅H₅₁N₇O₈
Chemical formulaC₃₅H₅₁N₇O₈
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin K
Primary Target K<sub>i</sub>6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219379-1MG 04055977201604

Documentation

Cathepsin K Inhibitor II - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Cathepsin K Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
219379

References

Reference overview
Wang, D., et al. 2002. Biochemistry 41, 8849.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-June-2008 RFH
SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
DescriptionA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
FormLyophilized white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₅H₅₁N₇O₈
Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.