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219417 Cathepsin Inhibitor II

Cathepsin Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-FG-NHO-BzME

Primary Target: cathepsin B
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₇H₂₇N₃O₆
Description
Overview

This product has been discontinued.





Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.3 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1).
Half-life in buffered solution (pH 5-9) = 27 h (30°C); 300 h (0°C).
Catalogue Number219417
Brand Family Calbiochem®
SynonymsZ-FG-NHO-BzME
References
ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Product Information
FormWhite solid
Hill FormulaC₂₇H₂₇N₃O₆
Chemical formulaC₂₇H₂₇N₃O₆
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>k₂/Ki = 6.9 x 10³ M⁻¹ sec⁻¹
Secondary targetcathepsin L (k₂/Ki = 3.1 x 10⁵ M⁻¹ sec⁻¹), cathepsin S (k₂/Ki = 4.3 x 10⁴ M⁻¹ sec⁻¹), and papain (k₂/Ki = 1.8 x 10³ M⁻¹ sec⁻¹)
Purity>90% by HPLC
Physicochemical Information
Peptide SequenceZ-Phe-Gly-NHO-Bz-pMe
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
219417 0

Documentation

Cathepsin Inhibitor II Certificates of Analysis

TitleLot Number
219417

References

Reference overview
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Brochure

Title
Cathepsins and Related Products Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-July-2011 JSW
SynonymsZ-FG-NHO-BzME
DescriptionCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.3 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1). Half-life in buffered solution (pH 5-9) = 27 h (30°C); 300 h (0°C).
FormWhite solid
Chemical formulaC₂₇H₂₇N₃O₆
Peptide SequenceZ-Phe-Gly-NHO-Bz-pMe
Structure formulaStructure formula
Purity>90% by HPLC
SolubilityAcetonitrile, DMSO, or Ethanol
Storage Protect from moisture
Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.