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218713 Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem

Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Keratinocyte Differentiation Inducer, 3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV

218713
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
863598-09-8C₂₄H₂₃N₅O₃
Description
Overview

This product has been discontinued.



A cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
Catalogue Number218713
Brand Family Calbiochem®
SynonymsKeratinocyte Differentiation Inducer, 3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV
References
ReferencesHong, J., et al. 2007. ACS Chem. Biol. 2, 171.
Product Information
CAS number863598-09-8
FormBeige solid
Hill FormulaC₂₄H₂₃N₅O₃
Chemical formulaC₂₄H₂₃N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months as supplied.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218713 0

Documentation

Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem Certificates of Analysis

TitleLot Number
218713

References

Reference overview
Hong, J., et al. 2007. ACS Chem. Biol. 2, 171.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2012 JSW
SynonymsKeratinocyte Differentiation Inducer, 3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV
DescriptionA cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number863598-09-8
Chemical formulaC₂₄H₂₃N₅O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (15 mg/ml) or Ethanol (3 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months as supplied.
Toxicity Standard Handling
ReferencesHong, J., et al. 2007. ACS Chem. Biol. 2, 171.