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236013 COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472

Primary Target: COX-2
236013
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1177728-24-3C₂₀H₂₁Cl₂N₃OS
Description
Overview

This product has been discontinued.



A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
Catalogue Number236013
Brand Family Calbiochem®
SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
References
ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
Product Information
CAS number1177728-24-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₁Cl₂N₃OS
Chemical formulaC₂₀H₂₁Cl₂N₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-2
Primary Target IC<sub>50</sub>at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
236013 0

Documentation

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem Certificates of Analysis

TitleLot Number
236013

References

Reference overview
Michaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
DescriptionA thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1177728-24-3
Chemical formulaC₂₀H₂₁Cl₂N₃OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Ethanol (0.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.