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236011 COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem

The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate

Primary Target: COX-2 from human monocytes
236011
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
416901-58-1C₁₈H₁₆ClNO₄S
Description
OverviewA cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 > 10 µM) and in whole blood (IC50 > 100 µM).
Catalogue Number236011
Brand Family Calbiochem®
SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
References
ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.
Product Information
CAS number416901-58-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₈H₁₆ClNO₄S
Chemical formulaC₁₈H₁₆ClNO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-2 from human monocytes
Primary Target IC<sub>50</sub>650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
236011 0

Documentation

COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem Certificates of Analysis

TitleLot Number
236011

References

Reference overview
Palomer, A., et al. 2002. J. Med. Chem. 45, 1402.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
DescriptionA cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number416901-58-1
Chemical formulaC₁₈H₁₆ClNO₄S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or MeOH (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.