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GF178 C1 Inhibitor,
Human Recombinant

C1 Inhibitor,
Human Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P05155
GF178
200µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
Protein is expressed in E.coli.Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF178
DescriptionC1 Inhibitor,
Human Recombinant
Alternate Names
  • C1 Inh
  • C1 esterase inhibitor
  • Serpin G1
Background InformationC1 Inhibitor is a member of the serpin family of structurally related proteins, and is the primary regulator of the immune complement system. C1 Inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa.
Recombinant Human C1 Inhibitor is a highly glycosylated glycoprotein containing 445 amino acid residues (49.4kDa), corresponding to amino acids 56 – 500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex.
References
Product Information
PresentationProduct is presented in 10mM Sodium Phosphate, pH 7.5 and is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceProtein is expressed in E.coli.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceMeasured by its ability to inhibit recombinant human complement component C1a cleavage of a colorimetric peptide substrate, N Carbobenzyloxy-Lys- ThioBenzyl ester (Z-K-SBzl). The expected IC50 is ≤ 2.6 nM.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size200µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF178 04053252979552

Documentation

C1 Inhibitor,
Human Recombinant MSDS

Title

Safety Data Sheet (SDS) 

C1 Inhibitor,
Human Recombinant Certificates of Analysis

TitleLot Number
C1 Inhibitor, Human Recombinant - Q2449362 Q2449362
C1 Inhibitor, Human Recombinant 3071356
C1 Inhibitor, Human Recombinant - 3070779 3070779
C1 Inhibitor, Human Recombinant - 3204871 3204871
C1 Inhibitor, Human Recombinant - 3752729 3752729
C1 Inhibitor, Human Recombinant - 4058471 4058471
C1 Inhibitor, Human Recombinant - 4140605 4140605
C1 Inhibitor, Human Recombinant - 4187231 4187231
C1 Inhibitor, Human Recombinant Protein 3050587
C1 Inhibitor, Human Recombinant Recombinant Protein 3018698
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