Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

SCT091 BioTracker NIR-HO Live Cell Dye

Near-Infrared probe for imaging Hg2+-and ONOO− in mercury-induced oxidative stress studies.

SCT091
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCT091
DescriptionBioTracker NIR-HO Live Cell Dye
OverviewMercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to human health. Researchers are investigating the role of Hg2+-induced oxidative stress, via peroxynitrite (ONOO−) level upregulation, in the pathogenic mechanisms of mercury toxicity.

BioTracker NIR-HO Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and visualization of Hg2+-induced ONOO− generation in vitro and in vivo. This fluorescent probe was designed with a “dual-key-and-lock” strategy where emission can only be switched on in the presence of both Hg2+ and ONOO− (1). It provides an effective method for detecting and imaging Hg2+ and ONOO- in oxidative stress studies and in the development of detoxifying drugs.

Spectral Properties
Excitation: 550 nm
Emission: 680 nm

Reference:
1. Yang, Xiaopeng, et al. "Imaging Hg2+-induced oxidative stress by NIR molecular probe with “dual-key-and-lock” strategy." Analytical Chemistry 92.17 (2020): 12002-12009.
Alternate Names
  • Live Cell Imaging Probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized. Yellow solid.
Applications
ApplicationNear-Infrared probe for imaging Hg2+-and ONOO− in mercury-induced oxidative stress studies.
Biological Information
Molecular Weight506.6
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT091 04065265944496