196810 Sigma-AldrichBax-Inhibiting Peptide, V5 - Calbiochem
Bax-Inhibiting Peptide, V5, CAS 579492-81-2, is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 µM).
More>> Bax-Inhibiting Peptide, V5, CAS 579492-81-2, is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 µM). Less<<Bax-Inhibiting Peptide, V5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: BIP-V5, H-VPMLK-OH
Recommended Products
 Antibody[219217-ALL].jpg)
 Antibody[214207-ALL].jpg)
Overview
| Replacement Information |
|---|
Key Spec Table
| Empirical Formula |
|---|
| C₂₇H₅₀N₆O₆S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 196810-5MG | Plastová ampulka | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain that offers cytoprotection. Functions as effectively as the Caspase Inhibitor VI (Z-VAD-FMK; Cat. No. 219007) for Bax-mediated apoptosis (~50-200 µM). Also effectively blocks caspase-independent necrotic cell death. Shown to be Ku70 competitive, interact with Bax, prevent its conformational change and mitochondrial translocation. Displays extended stability in culture medium (~3 days). Negative control peptide is also available (Cat. No. 196811). |
| Catalogue Number | 196810 |
| Brand Family | Calbiochem® |
| Synonyms | BIP-V5, H-VPMLK-OH |
| References | |
|---|---|
| References | Yoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961. Sawada, M., et al. 2003. Nature Cell Biol. 5, 352. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White lyophilized solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₂₇H₅₀N₆O₆S |
| Chemical formula | C₂₇H₅₀N₆O₆S |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Bax mediated apoptosis |
| Primary Target IC<sub>50</sub> | 50-200 µM against Bax mediated apoptosis |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | H-Val-Pro-Met-Leu-Lys-OH |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 196810-5MG | 04055977206548 |
Documentation
Bax-Inhibiting Peptide, V5 - Calbiochem MSDS
| Title |
|---|
Bax-Inhibiting Peptide, V5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 196810 |
References
| Reference overview |
|---|
| Yoshida, T., et al. 2004. Biochem. Biophys. Res. Commun. 321, 961. Sawada, M., et al. 2003. Nature Cell Biol. 5, 352. |
Brochure
| Title |
|---|
| Caspases and other Apoptosis Related Tools Brochure |