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194975 B-Cell Immunosuppressant

A cell-permeable quinolinecarboxamide that acts as a potent and highly selective B-cell immunosuppressant with a 75-fold selectivity for B- over T-cells and no general cytotoxicity.

B-Cell Immunosuppressant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[5-(Trifluoromethyl)pyridin-2-yl]quinole-8-carboxamide

194975
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
237067-55-9C₁₆H₁₀F₃N₃O
Description
Overview

This product has been discontinued.





A cell-permeable quinolinecarboxamide that acts as a potent and highly selective B-cell immunosuppressant with a 75-fold selectivity for B- over T-cells and no general cytotoxicity. Does not affect DHO- and IMP-dehydrogenases, or the kinase activities of EGFR, PDGFR, Cdk2, and Src (IC50 > 30 µM). Shown to effectively block TI (T-cell signal independent) Ab production in vivo (ED50 ≤ 3 mg/kg/day, administered subcutaneously or orally in mice). It is ~100-fold superior to Leflunomide (0.3 mg/kg/day v.s. 50mg/kg/day, respectively) in suppressing Ab-mediated xenograft rejection in a mouse xenotransplantation model.
Catalogue Number194975
Brand Family Calbiochem®
SynonymsN-[5-(Trifluoromethyl)pyridin-2-yl]quinole-8-carboxamide
References
ReferencesPapageorgiou, C., et al. 2001. J. Med. Chem. 44, 1986.
Product Information
CAS number237067-55-9
FormWhite solid
Hill FormulaC₁₆H₁₀F₃N₃O
Chemical formulaC₁₆H₁₀F₃N₃O
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
194975 0

Documentation

B-Cell Immunosuppressant MSDS

Title

Safety Data Sheet (SDS) 

B-Cell Immunosuppressant Certificates of Analysis

TitleLot Number
194975

References

Reference overview
Papageorgiou, C., et al. 2001. J. Med. Chem. 44, 1986.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsN-[5-(Trifluoromethyl)pyridin-2-yl]quinole-8-carboxamide
DescriptionA cell-permeable, potent, and highly selective B-cell immunosuppressant with 75-fold greater selectivity for B-cells compared to T-cells, with no general cytotoxic effects. Does not affect DHO- and IMP-dehydrogenases, or EGFR, PDGFR, Cdk2, and Src kinase activities (IC50 >30 µM). Reported to effectively block T-cell signal independent (TI) antibody(Ab) production in mice (ED50 <3 mg/kg/day, administered subcutaneously or orally). Shown to be ~100-fold more effective that Leflunomide (0.3 mg/kg/day vs. 50 mg/kg/day, respectively) in suppressing Ab-mediated xenograft rejection in a mouse xenotransplantation model.
FormWhite solid
CAS number237067-55-9
Chemical formulaC₁₆H₁₀F₃N₃O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml) or Methanol (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPapageorgiou, C., et al. 2001. J. Med. Chem. 44, 1986.