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07-807 Sigma-AldrichAnti-phospho-Met (Tyr1003) Antibody

Anti-phospho-Met (Tyr1003) Antibody is an antibody against phospho-Met (Tyr1003) for use in WB.

Anti-phospho-Met (Tyr1003) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: MET, AUTS9, c-Met, RCCP2, HGFR UniProt Number: P08581

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	07-807
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-phospho-Met (Tyr1003) Antibody
Alternate Names	c-Met cmet HGFR RCCP2 met proto-oncogene (hepatocyte growth factor receptor)

References

Product Information
Format	Affinity Purified
Presentation	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Quality Level	MQ100

Applications
Application	Anti-phospho-Met (Tyr1003) Antibody is an antibody against phospho-Met (Tyr1003) for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Met (Tyr1003).
Host	Rabbit
Specificity	Recognizes Met phosphorylated on Tyr1003.
Isotype	IgG
Species Reactivity	Human
Species Reactivity Note	Predicted to cross-react with Mouse and rat based on complete sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_000245.2
Entrez Gene Summary	The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
Gene Symbol	MET AUTS9 c-Met RCCP2 HGFR
Modifications	Phosphorylation
Purification Method	ImmunoAffinity Purified
UniProt Number	P08581
UniProt Summary	FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. SIZE: 1390 amino acids; 155527 Da SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.
Molecular Weight	155 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by immunoblot.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Storage and Shipping Information

Storage Conditions

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
07-807	04053252735264

Documentation

Anti-phospho-Met (Tyr1003) Antibody MSDS

Title
Safety Data Sheet (SDS)

Anti-phospho-Met (Tyr1003) Antibody Certificates of Analysis

Title	Lot Number
Anti-phospho-Met (Tyr1003) - 0605029599	0605029599
Anti-phospho-Met (Tyr1003) - DAM1408791	DAM1408791

References

Reference overview	Pub Med ID
A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells Hov, Håkon, et al Clin Cancer Res, 10:6686-94 (2004) 2004	15475459

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