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MAB390-100UG Anti-p75 LNGFR Antibody, Saporin conjugated, clone 192

MAB390-100UG
100 µg  
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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RILMSaporinMonoclonal Antibody
Description
Catalogue NumberMAB390-100UG
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-p75 LNGFR Antibody, Saporin conjugated, clone 192
Alternate Names
  • p75 Low Affinity Neurotrophin Receptor
  • NGFR
Product Information
FormatSaporin
PresentationSaporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco's PBS with no preservative.
Quality LevelMQ100
Applications
ApplicationAnti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 is an antibody against p75 Low Affinity Nerve Growth Factor Receptor for use in 0.
Key Applications
  • Immunolesioning
Application NotesImmunotoxin (see "Protocols" for Technical Notes)
Biological Information
Clone192
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP
IsotypeIgG1
Species Reactivity
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryNerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
Gene Symbol
  • NGFR
  • p75(NTR)
  • TNFRSF16
  • Gp80-LNGFR
  • CD271
Non-Reactive Species
  • Human
  • Mouse
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SIZE: 427 amino acids; 45183 Da
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsCentrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible.
Packaging Information
Material Size100 µg
Global Trade Item Number
Catalogue Number GTIN
MAB390-100UG 04053252610103