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ABF124 Anti-cGAS Antibody

This Anti-cGAS antibody is validated for use in Western Blotting for the detection of cGAS.

Anti-cGAS Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: MB21D1, C6orf150 UniProt Number: Q8N884
ABF124
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF124
DescriptionAnti-cGAS Antibody
Alternate Names
  • Cyclic GMP-AMP synthase
  • cGAMP synthase
  • cGAS
  • h-cGAS
  • Mab-21 domain-containing protein 1
Background InformationCyclic GMP-AMP synthase (cGAS), also known as cGAMP synthase, h-cGAS, Mab-21 domain-containing protein 1, and encoded by the gene name MB21D1 and C6orf150, is a member of the MAB-21 family. Cyclic GMP-AMP synthase (cGAS) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. The catalysis process involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Recent studies have indicated that Cyclic GMP-AMP synthase (cGAS) has an antiviral activity by acting as a key cytosolic DNA sensor, when the presence of double-stranded DNA (dsDNA) in the cytoplasm acts as a danger signal that triggers the immune responses. Cyclic GMP-AMP synthase (cGAS) then binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cyclic GMP-AMP synthase (cGAS) is expressed in the monocytic cell line THP1.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-cGAS antibody is validated for use in Western Blotting for the detection of cGAS.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human cGAS near the C-terminus.
EpitopeNear C-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MB21D1
  • C6orf150
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~54 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in MDA-MB-231 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected cGAS in 10 µg of MDA-MB-231 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABF124 04055977117028