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PC37 Anti-VEGF (Ab-2) Rabbit pAb

Anti-VEGF (Ab-2) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF

PC37
  
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Overview

Replacement Information

Key Spec Table

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes the ~46 kDa (dimer) VEGF protein in fetal tissue.
Catalogue NumberPC37
Brand Family Calbiochem®
SynonymsAnti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF
References
ReferencesKlagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
Brown, L., et al. 1992. Kidney International 42, 1457.
Dvorak, H., et al. 1991. Exp. Med. 174, 1275.
Product Information
FormLiquid
FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
Positive controlRecombinant VEGF protein
Preservative≤0.1% sodium azide
Applications
Application ReferencesParaffin Sections Klein, M., et al. 1999. J. Endrocrin. 161 41. Mouse Cross-Reactivity Villegas, G., et al. 2005. Kidney International 67, 449.
Key Applications Immunoblotting (Western Blotting)
Paraffin Sections
Application NotesImmunoblotting (2.5 µg/ml)
Paraffin sections (5 µg/ml, trypsin pre-treatment required, see application references)
Application CommentsAntibody should be titrated for optimal results in individual systems.
Biological Information
Immunogena synthetic peptide corresponding to amino acids at the extreme N-terminus of human VEGF₁₆₅
ImmunogenHuman
HostRabbit
IsotypeIgG
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Yes
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
PC37 0

Documentation

Anti-VEGF (Ab-2) Rabbit pAb MSDS

Title

Safety Data Sheet (SDS) 

Anti-VEGF (Ab-2) Rabbit pAb Certificates of Analysis

TitleLot Number
PC37

References

Reference overview
Klagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
Brown, L., et al. 1992. Kidney International 42, 1457.
Dvorak, H., et al. 1991. Exp. Med. 174, 1275.

Citations

Title
  • Guillermo Villegas, Baerbel Lange-Sperandio and Alda Tufro. (2005) Autocrine and Paracrine Functions of Vascular Endothelial Growth Factor (VEGF) in Renal Tubular Epithelial Cells. Kidney International 67, 449-457.
  • M. Klein, et al. (1999) Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. Journal of Endocrinology 161, 41-49.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-October-2007 RFH
    SynonymsAnti-Vascular Endothelial Growth Factor, Anti-Vascular Permeability Factor, Anti-VPF
    ApplicationImmunoblotting (2.5 µg/ml)
    Paraffin sections (5 µg/ml, trypsin pre-treatment required, see application references)
    DescriptionPurified rabbit polyclonal antibody. Recognizes the VEGF121, VEGF165, VEGF189, and VEGF206 forms of VEGF.
    BackgroundVascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a secreted heparin binding cytokine expressed in tumor and animal cells. It has been implicated in the control of angiogenesis due to its selective mitogenic stimulation of vascular endothelial cells and enhancement of vascular permeability. Other effects of VEGF on vascular endothelial cells include; increasing intracellular calcium, stimulating inositol triphosphate formation, induction of von Willebrand factor release, and stimulating tissue factor expression. VEGF is a ~46 kDa dimer of two identical disulfide-linked subunits existing in four molecular species; 121, 165, 189, and 206 amino acid residues long.
    HostRabbit
    Immunogen speciesHuman
    Immunogena synthetic peptide corresponding to amino acids at the extreme N-terminus of human VEGF₁₆₅
    IsotypeIgG
    Specieshuman, mouse
    Positive controlRecombinant VEGF protein
    FormLiquid
    FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
    Concentration Label Please refer to vial label for lot-specific concentration
    Preservative≤0.1% sodium azide
    CommentsAntibody should be titrated for optimal results in individual systems.
    Storage +2°C to +8°C
    Do Not Freeze Yes
    Toxicity Standard Handling
    ReferencesKlagsbrun, M., and Soker, S., 1993. Current Biology 3, 699.
    Senger, D., et al. 1993. Cancer Metastasis Rev. 12, 303.
    Brown, L., et al. 1992. Kidney International 42, 1457.
    Dvorak, H., et al. 1991. Exp. Med. 174, 1275.
    Citation
  • Guillermo Villegas, Baerbel Lange-Sperandio and Alda Tufro. (2005) Autocrine and Paracrine Functions of Vascular Endothelial Growth Factor (VEGF) in Renal Tubular Epithelial Cells. Kidney International 67, 449-457.
  • M. Klein, et al. (1999) Vascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma. Journal of Endocrinology 161, 41-49.
    		•
    Application referencesParaffin Sections Klein, M., et al. 1999. J. Endrocrin. 161 41. Mouse Cross-Reactivity Villegas, G., et al. 2005. Kidney International 67, 449.