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MAB318-AF488 Sigma-AldrichAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
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Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: TH, TYH UniProt Number: P07101

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
Zebrafish, Ch, Fg, H, M, R	ICC	M	AlexaFluor®488	Monoclonal Antibody

Description
Catalogue Number	MAB318-AF488
Description	Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Alternate Names	Tyrosine 3-monooxygenase Tyrosine Hydroxylase Tyrosine 3-hydroxylase TH
Background Information	Tyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).

References

Product Information
Format	AlexaFluor®488
Presentation	Purified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.
Key Applications	Immunocytochemistry
Application Notes	The unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.

Biological Information
Immunogen	Tyrosine Hydroxylase purified from PC12 cells.
Epitope	On the outside of the regulatory N-terminus of tyrosine hydroxylase.
Clone	LNC1
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Recognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. Does not react with dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, or phenethanolamine-N-methyl transferase (PNMT) by Western blotting using the unconjugated antibody (Cat. No. MAB318).
Isotype	IgG1κ
Species Reactivity	Zebrafish Chicken Frog Human Mouse Rat
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_000360.3
Gene Symbol	TH TYH
Purification Method	Protein A Purfied
UniProt Number	P07101
Molecular Weight	~59-63 kDa observed

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunocytochemistry in rat cortical neurons. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
MAB318-AF488	04055977301168

Documentation

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate MSDS

Title
Safety Data Sheet (SDS)

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate Certificates of Analysis

Title	Lot Number
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3990647	3990647
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3991543	3991543
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4076671	4076671
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4091251	4091251
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4124273	4124273
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4219961	4219961
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate -2888816	2888816
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3011479	3011479
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3185617	3185617
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3231935	3231935

Brochure

Title
Neuroscience Solutions for productive research

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