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MABT390 Anti-Syntaxin-2 Antibody, clone 2F2.1

Anti-Syntaxin-2 Antibody, clone 2F2.1 is a highly specific mouse monoclonal antibody, that targets Syntaxin 2 & has been tested in western blotting & ICC.

Anti-Syntaxin-2 Antibody, clone 2F2.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeletal Signaling Gene Symbol: STX2, EPIM, STX2A, STX2B, STX2C UniProt Number: P32856
MABT390
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT390
DescriptionAnti-Syntaxin-2 Antibody, clone 2F2.1
Alternate Names
  • Syntaxin-2
  • Epimorphin
Background InformationThe protein named Syntaxin-2 or Epimorphin is a multifunctional membrane protein with dual topology. Its C terminus is membrane anchored. When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out the N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called Epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces, and Syntaxin-2 is protein that is essential for epithelial cell and tissue morphogenesis and synaptic function in nervous system communication. Syntaxin-2 interacts with synaptotagmin-6 (SYT6) and synaptotagmin-8 (SYT8) in calcium dependent exocytosis of synaptic vesicles and may mediate calcium regulation of exocytosis in the acrosomal reaction in sperm cells as well.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Syntaxin-2 Antibody, clone 2F2.1 is a highly specific mouse monoclonal antibody, that targets Syntaxin 2 & has been tested in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Syntaxin-2 in SH-SY5Y cells.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human Syntaxin-2.
Clone2F2.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • STX2
  • EPIM
  • STX2A
  • STX2B
  • STX2C
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~ 33 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Syntaxin-2 in 200 µg of SH-SY5Y cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABT390 04053252934025