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AB5358-200UL Anti-Sodium Channel NaB2 Antibody

Anti-Sodium Channel NaB2 Antibody detects level of Sodium Channel NaB2 & has been published & validated for use in IH & WB.

Anti-Sodium Channel NaB2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN2B, ORFNames=UNQ326/PRO386 UniProt Number: O60939
AB5358-200UL
200 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RIHC, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB5358-200UL
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Sodium Channel NaB2 Antibody
Alternate Names
  • B2 Subunit of Voltage-Gated Na+ Channel
  • SCN2B
References
Product Information
FormatAffinity Purified
Control
  • CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
PresentationAffinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, and 0.05 % sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).
Quality LevelMQ100
Applications
ApplicationAnti-Sodium Channel NaB2 Antibody detects level of Sodium Channel NaB2 & has been published & validated for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application NotesWestern blotting: 1:200 on rat brain membranes.

Immunohistochemistry on rat brain sections.

Dilutions should be made using a carrier protein such as BSA (1-3%).

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenHighly purified peptide corresponding to residues 197-215 of rat beta2 subunit of voltage-gated Na+ channels (Isom et al. 1995). Accession P54900. It is expected to work on human because the immunogen sequence is highly conserved (17/19 residues). Reactivity with other species has not yet been tested.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes Nab2. The epitope specific for Nab2 is not present in any other known proteins.
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SCN2B
  • ORFNames=UNQ326/PRO386
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O60939 # Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
SIZE: 215 amino acids; 24326 Da
SUBUNIT: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: SwissProt: O60939 ## Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C for up to 6 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB5358-200UL 04053252511387

Documentation

Anti-Sodium Channel NaB2 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Sodium Channel NaB2 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-Nab2 (b2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2003671 2003671
RABBIT ANTI-Nab2 (b2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2197190 2197190
RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) - 4020595 4020595
RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3026852
RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3038008

Data Sheet

Title
RABBIT ANTI-Na2 (2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY