Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

481906 Anti-Nicastrin, N-Terminal (62-93) Rabbit pAb

Anti-Nicastrin, N-Terminal (62-93) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-SP716

481906
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes the latent and active forms of nicastrin.
Catalogue Number481906
Brand Family Calbiochem®
SynonymsAnti-SP716
References
ReferencesLeem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
Yu, G., et al. 2000. Nature 407, 34.
Product Information
FormLiquid
FormulationUndiluted serum.
PreservativeNone
Applications
Key Applications Immunoblotting (Western Blotting)
Immunofluorescence
Immunoprecipitation
Application NotesImmunoblotting (1:1000-1:2000)
Immunofluorescence (1:200)
Immunoprecipitation (2 µl/mg protein)
Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogena synthetic peptide (CQSSISGDTGVIHVVEKEEDLKWVLTDGPNPP) corresponding to amino acids 62-93 of human nicastrin, conjugated to KLH
ImmunogenHuman
HostRabbit
IsotypeIgG
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
481906 0

Documentation

Anti-Nicastrin, N-Terminal (62-93) Rabbit pAb Certificates of Analysis

TitleLot Number
481906

References

Reference overview
Leem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
Yu, G., et al. 2000. Nature 407, 34.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2007 RFH
SynonymsAnti-SP716
ApplicationImmunoblotting (1:1000-1:2000)
Immunofluorescence (1:200)
Immunoprecipitation (2 µl/mg protein)
DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the latent and active forms of nicastrin.
BackgroundNicastrin is a transmembrane glycoprotein that forms high molecular weight complexes with presensilin 1 and presensilin 2. It binds carboxy-terminal derivatives of beta-amyloid precursor protein (βAPP), and modulates the production of the amyloid β-peptide (Aβ) from these derivatives. Deposits of this amyloid beta-peptide form the amyloid plaques that characterize Alzheimer's disease.
HostRabbit
Immunogen speciesHuman
Immunogena synthetic peptide (CQSSISGDTGVIHVVEKEEDLKWVLTDGPNPP) corresponding to amino acids 62-93 of human nicastrin, conjugated to KLH
IsotypeIgG
Specieshuman, mouse
FormLiquid
FormulationUndiluted serum.
PreservativeNone
CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesLeem, J.Y., et al. 2002. J. Biol. Chem. 277, 19236.
Yu, G., et al. 2000. Nature 407, 34.