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05-170 Anti-IL-2 Rα Antibody, clone 7G7/B6

05-170
200 µg  
Purchase on Sigma-Aldrich

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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HDB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue Number05-170
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-IL-2 Rα Antibody, clone 7G7/B6
Product Information
FormatPurified
Control
  • Lung tissue
PresentationProtein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
Quality LevelMQ100
Applications
ApplicationThis Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.
Key Applications
  • Dot Blot
  • Immunocytochemistry
Biological Information
ImmunogenWhole cells expressing human IL-2 Receptor α
Clone7G7/B6
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes interleukin-2 receptor.
IsotypeIgG2a
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.
Gene Symbol
  • IL2RA
  • CD25
  • IL2-RA
  • IL-2-RA
  • OTTHUMP00000044870
  • TCGFR
  • IL2R
  • IDDM10
  • p55
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01589 # Receptor for interleukin-2.
SIZE: 272 amino acids; 30819 Da
SUBUNIT: Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE:SwissProt: P01589 # Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942].
SIMILARITY: SwissProt: P01589 ## Contains 2 Sushi (CCP/SCR) domains.
Molecular Weight55 kDa
Product Usage Statements
Quality Assuranceroutinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C
Packaging Information
Material Size200 µg
Global Trade Item Number
Catalogue Number GTIN
05-170 04053252323386