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ABF191-25UL Anti-FcRn (FCGRT)

This rabbit polyclonal Anti-FcRn (FCGRT) antibody, Cat. No. ABF191, detects IgG receptor FcRn large subunit p51. It has been tested for use in Immunofluorescence and Western Blotting.

Anti-FcRn (FCGRT) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Fcgrt, Fcrn UniProt Number: Q61559
ABF191-25UL
25 µL  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MIF, WBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABF191-25UL
DescriptionAnti-FcRn (FCGRT)
Alternate Names
  • IgG receptor FcRn large subunit p51
  • IgG Fc fragment receptor transporter alpha chain
  • Neonatal Fc receptor
Background InformationIgG receptor FcRn large subunit p51 (UniProt: Q61559; also known as FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor) is encoded by the Fcgrt (also known as Fcrn) gene (Gene ID: 14132) in murine species. FcRn is a single-pass type I membrane protein that binds to the Fc region of monomeric immunoglobulins gamma. FcRn complex consist of two subunits: p51 and p14 and contains one Ig-like C1-type (immunoglobulin-like) domain of 88 amino acids. FcRn mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. In rodents, FcRn functions effectively in the neonatal period when it transports maternally derived IgG in ingested milk across the epithelial-cell layer of the proximal small intestine. However, in humans it transports maternal antibody to the fetus across the placenta. In rodent FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. FcRn also protects IgG from degradation providing long half-life of this class of antibody in the serum. (Ref.: Roopenian,, DC and Shreeram,, A (2007). Nat. Rev. Immunol. 7(9); 715-725).
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationThis rabbit polyclonal Anti-FcRn (FCGRT) antibody, Cat. No. ABF191, detects IgG receptor FcRn large subunit p51. It has been tested for use in Immunofluorescence and Western Blotting.
Key Applications
  • Immunofluorescence
  • Western Blotting
Application NotesImmunofluorescence Analysis: A representative lot detected FcRn (FCGRT) in mouse uterus and vagina (Li, Z., et. al. (2011). Proc Natl Acad Sci USA. 108(11):4388-93).

Western Blotting Analysis: A representative lot detected FcRn (FCGRT) in mouse liver, mouse uterus, and vagina tissue lysate (Li, Z., et. al. (2011). Proc Natl Acad Sci USA. 108(11):4388-93).
Biological Information
ImmunogenGST-tagged recombinant fragment corresponding to 44 amino acids from the C-terminal region of murine IgG receptor FcRn large subunit p51.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis polyclonal antibody detects murine IgG receptor FcRn. It targets an epitope within 44 amino acids from the C-terminal region.
IsotypeIgG
Species Reactivity
  • Mouse
Species Reactivity NoteMouse.
Antibody TypePolyclonal Antibody
Gene Symbol
  • Fcgrt
  • Fcrn
Purification MethodAffinity Purified
UniProt Number
Molecular Weight53 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected FcRn (FCGRT) in 10 µg of m ouse liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABF191-25UL 04054839480140