Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB10080 Anti-CYP450 Antibody, clone 2E1

Anti-CYP450 Antibody, clone 2E1 is an antibody against CYP450 for use in WB.

Anti-CYP450 Antibody, clone 2E1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: CYP2E1, OTTHUMP00000046571, CYPIIE1, CYP2E, P450C2E, P450-J, CPE1 UniProt Number: P05181
AB10080
50 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB10080
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-CYP450 Antibody, clone 2E1
Alternate Names
  • cytochrome P450
References
Product Information
FormatSerum
PresentationRaw Rabbit Serum with 0.1% Sodium Azide
Quality LevelMQ100
Applications
ApplicationAnti-CYP450 Antibody, clone 2E1 is an antibody against CYP450 for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenRecombinant CYP450 2E1
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Gene Symbol
  • CYP2E1
  • OTTHUMP00000046571
  • CYPIIE1
  • CYP2E
  • P450C2E
  • P450-J
  • CPE1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs to the cytochrome P450 family.
Molecular Weight57 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at 2-8°C from date of shipment
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB10080 04053252514838

Documentation

Anti-CYP450 Antibody, clone 2E1 MSDS

Title

Safety Data Sheet (SDS) 

Anti-CYP450 Antibody, clone 2E1 Certificates of Analysis

TitleLot Number
Anti-CYP450, clone 2E1 POLYCLONAL ANTIBODY Q2912990

References

Reference overviewPub Med ID
Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity
Viaggi, C, et al
J Neural Transm Suppl, :173-6 (2006)  2005

17017526 17017526
Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite
Cannady, Ellen A, et al
Toxicol Sci, 73:423-30 (2003)  2003

12700394 12700394

Data Sheet

Title
RABBIT ANTI- CYP450 2E1 POLYCLONAL ANTIBODY