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MABF450 Sigma-AldrichAnti-CD62L (L-Selectin) Antibody (mouse), APC, clone MEL-14

This rat monoclonal antibody Anti-CD62L (L-Selectin) (mouse), APC, clone MEL-14 validated for use in IP, IHC & Flow Cytometry for the detection of CD62L (L-Selectin).

Anti-CD62L (L-Selectin) Antibody (mouse), APC, clone MEL-14 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Research Category: Inflammation & Immunology Gene Symbol: Sell, Lnhr, Ly-22, Ly22 UniProt Number: P18337

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	IP, IHC, FC	R	APC	Monoclonal Antibody

Description
Catalogue Number	MABF450
Description	Anti-CD62L (L-Selectin) Antibody (mouse), APC, clone MEL-14
Alternate Names	L-selectin CD62 antigen-like family member L Leukocyte adhesion molecule 1 LAM-1 Leukocyte-endothelial cell adhesion molecule 1 LECAM1 Lymph node homing receptor Lymphocyte antigen 22 Ly-22 Lymphocyte surface MEL-14 antigen CD62L
Background Information	The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte “rolling” on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.

References

Product Information
Format	APC
Presentation	Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Quality Level	MQ100

Applications
Application	This rat monoclonal antibody Anti-CD62L (L-Selectin) (mouse), APC, clone MEL-14 validated for use in IP, IHC & Flow Cytometry for the detection of CD62L (L-Selectin).
Key Applications	Immunoprecipitation Immunohistochemistry Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	MEL-14
Concentration	0.2 mg/mL
Host	Rat
Isotype	IgG2aκ
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Sell Lnhr Ly-22 Ly22
Purification Method	Size Exclusion Chromatography
UniProt Number	P18337

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.06 μg of this antibody detected CD62L (L-Selectin) in one million C57Bl/6 splenocytes.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
MABF450	04053252960406

Documentation

Anti-CD62L (L-Selectin) Antibody (mouse), APC, clone MEL-14 MSDS

Title
Safety Data Sheet (SDS)

Anti-CD62L (L-Selectin) Antibody (mouse), APC, clone MEL-14 Certificates of Analysis

Title	Lot Number
Anti-CD62L (L-Selectin) (mouse), APC, clone MEL-14 - TN14010810	TN14010810

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