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116825 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt

116825
  
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Overview

Key Spec Table

CAS #Empirical Formula
152218-23-0C₁₄H₁₇N₅O₆PS · Na
Description
Overview

This product has been discontinued.





A cell-permeable, metabolically-stable precursor of Rp-cAMPS (Cat. No. 116814) that acts as a competitive inhibitor of protein kinase A type I and II. During metabolic activation by esterases, the inhibitor and butyrate are released. Reported to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. More lipophilic and cell-permeable than Rp-cAMPS.
Note: 5 µmol = 2.19 mg.
Catalogue Number116825
Brand Family Calbiochem®
SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
References
ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
Product Information
CAS number152218-23-0
ATP CompetitiveY
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₄H₁₇N₅O₆PS · Na
Chemical formulaC₁₄H₁₇N₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Biological Information
Primary TargetPKA1, PKA2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
116825 0