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28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dibutyryl-cAMP, Na

Primary Target: PKA
28745
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
16980-89-5C₁₈H₂₃N₅O₈P · Na

Products

Catalogue NumberPackaging Qty/Pack
28745-100MG Plastová ampulka 100 mg
28745-25MG Plastová ampulka 25 mg
Description
OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
Catalogue Number28745
Brand Family Calbiochem®
SynonymsDibutyryl-cAMP, Na
References
ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
Product Information
CAS number16980-89-5
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₁₈H₂₃N₅O₈P · Na
Chemical formulaC₁₈H₂₃N₅O₈P · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetPKA
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSES5055500
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
28745-100MG 04055977197839
28745-25MG 04055977090970

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem Certificates of Analysis

TitleLot Number
28745

References

Reference overview
Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-March-2008 JSW
SynonymsDibutyryl-cAMP, Na
DescriptionCell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Known to cause an increase in the steady state level of the parathyroid hormone related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
FormWhite lyophilized solid
CAS number16980-89-5
RTECSES5055500
Chemical formulaC₁₈H₂₃N₅O₈P · Na
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
Toxicity Standard Handling
ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.