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658403 AG 538 - CAS 133550-18-2 - Calbiochem

A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC₅₀ = 400 nM).

AG 538 - CAS 133550-18-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538

Primary Target: IGF-1 receptor kinase
658403
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Overview

Key Spec Table

CAS #Empirical Formula
133550-18-2C₁₆H₁N₁₁O₅

Products

Catalogue NumberPackaging Qty/Pack
658403-5MG Plastová ampulka 5 mg
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Description
OverviewA potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 µM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM).
Catalogue Number658403
Brand Family Calbiochem®
Synonymsα-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
References
ReferencesBlum, G., et al. 2000. Biochemistry 39, 15705.
Product Information
CAS number133550-18-2
ATP CompetitiveY
FormDark orange to brown solid
Hill FormulaC₁₆H₁N₁₁O₅
Chemical formulaC₁₆H₁N₁₁O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetIGF-1 receptor kinase
Primary Target IC<sub>50</sub>400 nM against IGF-1 receptor kinase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
658403-5MG 04055977261585