Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

658425 AG 17 - CAS 10537-47-0 - Calbiochem

Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM).

AG 17 - CAS 10537-47-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872

Primary Target: Platelet-derived growth factor receptor tyrosine kinase
658425
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
10537-47-0C₁₈H₂₂N₂O

Products

Catalogue NumberPackaging Qty/Pack
658425-5MG Hliníkový sud 5 mg
Description
OverviewAnti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
Catalogue Number658425
Brand Family Calbiochem®
SynonymsNSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
References
ReferencesFuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
Palumbo, G.A., et al. 1994. Blood 84, 296a.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
Terada, H. 1981. Biochim. Biophys. Acta 639, 225
Product Information
CAS number10537-47-0
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₁₈H₂₂N₂O
Chemical formulaC₁₈H₂₂N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPlatelet-derived growth factor receptor tyrosine kinase
Primary Target IC<sub>50</sub>500 nM against platelet-derived growth factor receptor tyrosine kinase
Purity≥99% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSOO3737000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658425-5MG 04055977261615

Documentation

AG 17 - CAS 10537-47-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

AG 17 - CAS 10537-47-0 - Calbiochem Certificates of Analysis

TitleLot Number
658425

References

Reference overview
Fuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
Palumbo, G.A., et al. 1994. Blood 84, 296a.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
Terada, H. 1981. Biochim. Biophys. Acta 639, 225

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
SynonymsNSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
DescriptionA selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
FormPale yellow solid
CAS number10537-47-0
RTECSOO3737000
Chemical formulaC₁₈H₂₂N₂O
Structure formulaStructure formula
Purity≥99% by TLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Toxic
ReferencesFuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
Palumbo, G.A., et al. 1994. Blood 84, 296a.
Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
Terada, H. 1981. Biochim. Biophys. Acta 639, 225