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101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP.

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl

Primary Target: chymotrypsin
101500
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
30827-99-7C₈H₁₀FNO₂S · HCl

Products

Catalogue NumberPackaging Qty/Pack
101500-100MG Sklená flaša 100 mg
101500-1GM Sklená flaša 1 gm
101500-500MG Plastová ampulka 500 mg
101500-50MG Sklená flaša 50 mg
Description
OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
Catalogue Number101500
Brand Family Calbiochem®
Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
Application Data
References
ReferencesCitron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
Product Information
CAS number30827-99-7
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₈H₁₀FNO₂S · HCl
Chemical formulaC₈H₁₀FNO₂S · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetchymotrypsin
Purity>97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
101500-100MG 04055977226317
101500-1GM 04055977226300
101500-500MG 04055977226348
101500-50MG 04055977226331

Documentation

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Certificates of Analysis

TitleLot Number
101500

References

Reference overview
Citron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.

Brochure

Title
Bulk Product Guide

Citations

Title
  • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision27-September-2013 JSW
    Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
    Application Data
    DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
    FormWhite to off-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number30827-99-7
    Chemical formulaC₈H₁₀FNO₂S · HCl
    Structure formulaStructure formula
    Purity>97% by HPLC
    SolubilityH₂O (25 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
    Toxicity Standard Handling
    ReferencesCitron, M., et al. 1996. Neuron 17, 171.
    Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
    Mintz, G.R. 1993. BioPharm. 6, 34.
    Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
    Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
    Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
    Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
    Citation
  • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
    		•