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104550 ACA - CAS 110683-10-8 - Calbiochem

A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

ACA - CAS 110683-10-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(p-Amylcinnamoyl)anthranilic Acid

Primary Target: A2PLA2
104550
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
110683-10-8C₂₁H₂₃NO₃

Products

Catalogue NumberPackaging Qty/Pack
104550-25MG Plastová ampulka 25 mg
Description
OverviewA cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.
Catalogue Number104550
Brand Family Calbiochem®
SynonymsN-(p-Amylcinnamoyl)anthranilic Acid
References
ReferencesLiu, L., et al. 1999. J. Cell. Biochem. 72, 103.
Simonsson, E., et al. 1998. Diabetes 47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.
Product Information
CAS number110683-10-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₁H₂₃NO₃
Chemical formulaC₂₁H₂₃NO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA2PLA2
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
104550-25MG 04055977226461

Documentation

ACA - CAS 110683-10-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

ACA - CAS 110683-10-8 - Calbiochem Certificates of Analysis

TitleLot Number
104550

References

Reference overview
Liu, L., et al. 1999. J. Cell. Biochem. 72, 103.
Simonsson, E., et al. 1998. Diabetes 47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2016 JSW
SynonymsN-(p-Amylcinnamoyl)anthranilic Acid
DescriptionInhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.
FormWhite solid
CAS number110683-10-8
Chemical formulaC₂₁H₂₃NO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityEthanol (10 mg/ml) or DMSO (50 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLiu, L., et al. 1999. J. Cell. Biochem. 72, 103.
Simonsson, E., et al. 1998. Diabetes 47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.