Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

565762 γ-Secretase Inhibitor V

γ-Secretase Inhibitor V MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal

Primary Target: Aβx-40 in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants
565762
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₂₈N₂O₄
Description
Overview

This product has been discontinued.





A cell-permeable, reversible inhibitor of γ-secretase that is reported to inhibit the release of Aβx-40 (ED50 = 5 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
Catalogue Number565762
Brand Family Calbiochem®
SynonymsZ-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal
References
ReferencesSinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Product Information
FormWhite lyophilized solid
Hill FormulaC₂₃H₂₈N₂O₄
Chemical formulaC₂₃H₂₈N₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAβx-40 in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants
Primary Target IC<sub>50</sub>ED₅₀ = 5 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Phe-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565762 0

Documentation

γ-Secretase Inhibitor V Certificates of Analysis

TitleLot Number
565762

References

Reference overview
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
SynonymsZ-LF-CHO, N-Benzyloxycarbonyl-Leu-phenylalaninal
DescriptionA cell-permeable, reversible inhibitor of g-secretase that inhibits the release of Aβx-40 (ED50 = 5.0 µM) from HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₈N₂O₄
Peptide SequenceZ-Leu-Phe-CHO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesSinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.