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565761 γ-Secretase Inhibitor IV - Calbiochem

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal

Primary Target: Aβx-40
565761
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₅H₂₆N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
565761-1MG Plastová ampulka 1 mg
Description
OverviewA cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
Catalogue Number565761
Brand Family Calbiochem®
Synonyms2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
References
ReferencesGreen, K.N., et al. 2002. J. Physiol. 541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₅H₂₆N₂O₃
Chemical formulaC₂₅H₂₆N₂O₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetAβx-40
Primary Target IC<sub>50</sub>ED50 = 2.6 µM for Aβx-40
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequence2-Naphthoyl-Val-Phe-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565761-1MG 04055977267716

Documentation

γ-Secretase Inhibitor IV - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

γ-Secretase Inhibitor IV - Calbiochem Certificates of Analysis

TitleLot Number
565761

References

Reference overview
Green, K.N., et al. 2002. J. Physiol. 541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
Synonyms2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
DescriptionA cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
FormWhite lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₂₆N₂O₃
Peptide Sequence2-Naphthoyl-Val-Phe-CHO
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGreen, K.N., et al. 2002. J. Physiol. 541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.