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376820 β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem

The β-Hexosaminidase Inhibitor, also referenced under CAS 281224-40-6, controls the biological activity of β-Hexosaminidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: M-31850

376820
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
281224-40-6C₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Description
Overview

This product has been discontinued.



A cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 and 3.1 µM for hHex A and hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
Catalogue Number376820
Brand Family Calbiochem®
SynonymsM-31850
References
ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.
Product Information
CAS number281224-40-6
FormWhite solid
Hill FormulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
376820 0

Documentation

β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem Certificates of Analysis

TitleLot Number
376820

References

Reference overview
Tropak, M.B., et al. 2007. Chem. Biol. 14, 153.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsM-31850
DescriptionA cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Recommended reaction conditions
Please Note: DMSO is known to exhibit inhibitory effects against hexosaminidase, therefore it is essential to include proper vehicle controls if a hexosaminidase inhibitor stock prepared in DMSO is used in studies involving hexosaminidase.
CAS number281224-40-6
Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
Toxicity Standard Handling
ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.