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534347 hCNT2 Inhibitor

Potently inhibits hCNT2-mediated Na+-dependent inosine uptake (IC₅₀ = 640 nM in COS-7 cells).

hCNT2 Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor

Primary Target: hCNT2
534347
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₃H₂₄N₆O₄
Description
Overview

This product has been discontinued.



An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Catalogue Number534347
Brand Family Calbiochem®
Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
DescriptionhCNT2 Inhibitor
References
ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
Product Information
FormPale yellow solid
Hill FormulaC₂₃H₂₄N₆O₄
Chemical formulaC₂₃H₂₄N₆O₄
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargethCNT2
Primary Target IC<sub>50</sub>640 nM in COS-7 cells
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
534347 0

Documentation

hCNT2 Inhibitor MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Tatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2016 JSW
Synonyms8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
DescriptionAn aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na+-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC50 of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₄N₆O₄
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTatani, K., et al. 2015. ACS Med. Chem. Lett. 6, 244.