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530654 c-Rel Inhibitor, IT-603 - CAS 292168-90-2 - Calbiochem

A cell-permeable compound that directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity (IC₅₀ = 3 µM).

c-Rel Inhibitor, IT-603 - CAS 292168-90-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (5Z)-5-((5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene)-2-sulfanylideneimidazolidin-4-one, (5Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxo-4-imidazolidinone, IT603

Primary Target: c-Rel
530654
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Přehled

Tabulka spec. kláve

CAS #Empirical Formula
292168-90-2C₁₁H₉BrN₂O₃S

Products

Katalogové čísloBalení ks/bal.
5.30654.0001 Skleněná láhev 10 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable benzylidene-thioxo-imidazolidinone compund that directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity (IC50 = 3 µM in EMSA). Shows good selectivity over Oct1 and AP1. Reduces IL-2 expression in activated T cells without affecting their viability. Induces growth arrest in diffuse large B-cell lymphoma (DLBCL) cell line Ly3 (IC50 = 18 uM). Shown to reduce alloactivation in T cells and diminish graft-versus-host disease (GVHD), but does not impair TCR-mediated killing. Improves the survival rate of lethally irradiated BABL/c mice transplanted with T cell depleted bone marrow cells from C57BL/6 mice (~24 mg/kg, i.p, daily).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530654
Brand Family Calbiochem®
Synonyms(5Z)-5-((5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene)-2-sulfanylideneimidazolidin-4-one, (5Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxo-4-imidazolidinone, IT603
References
ReferencesShono, Y., et al. 2014. Cancer Discovery 4, 578.
Product Information
CAS number292168-90-2
FormDark yellow powder
Hill FormulaC₁₁H₉BrN₂O₃S
Chemical formulaC₁₁H₉BrN₂O₃S
ReversibleY
Quality LevelMQ100
Biological Information
Primary Targetc-Rel
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.30654.0001 04055977260410