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684500 Zaprinast - CAS 37762-06-4 - Calbiochem

Zaprinast - CAS 37762-06-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948

Primary Target: cGMP-specific phosphodiesterase
684500
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
37762-06-4C₁₃H₁₃N₅O₂
Description
Overview

This product has been discontinued.



A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 450 nM). Inhibits PDE IX at higher concentration (IC50 = 35 µM). Also known to increase cGMP levels in spontaneously hypertensive rat (SHR) plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
Catalogue Number684500
Brand Family Calbiochem®
Synonyms1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
References
ReferencesFisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
Burns, F., et al. 1992. Biochem. J. 283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.
Product Information
CAS number37762-06-4
ATP CompetitiveN
FormTan to pink solid
Hill FormulaC₁₃H₁₃N₅O₂
Chemical formulaC₁₃H₁₃N₅O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetcGMP-specific phosphodiesterase
Primary Target IC<sub>50</sub>450 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.



From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
684500 0

Documentation

Zaprinast - CAS 37762-06-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Zaprinast - CAS 37762-06-4 - Calbiochem Certificates of Analysis

TitleLot Number
684500

References

Přehled odkazů
Fisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
Burns, F., et al. 1992. Biochem. J. 283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.

Citations

Název
  • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-April-2017 JSW
    Synonyms1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
    DescriptionSelective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 450 nM). Also known to increase cGMP levels in SHR plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
    FormTan to pink solid
    CAS number37762-06-4
    Chemical formulaC₁₃H₁₃N₅O₂
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (25 mg/ml) or ethanol (5 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.



    From Catalog:
    Desc. Field- added "cell-permeable
    Toxicity Irritant
    ReferencesFisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
    Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
    Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
    Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
    Burns, F., et al. 1992. Biochem. J. 283, 487.
    Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.
    Citation
  • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
    		•