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421050 (Z-LL)₂ Ketone - Calbiochem

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.

(Z-LL)₂ Ketone - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone

Primary Target: Processing of the p-Prl signal peptide
421050
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₄₃H₆₄N₆O₉
Description
OverviewA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
Catalogue Number421050
Brand Family Calbiochem®
Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
References
ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Product Information
ATP CompetitiveN
FormOff-white lyophilized solid
Hill FormulaC₄₃H₆₄N₆O₉
Chemical formulaC₄₃H₆₄N₆O₉
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetProcessing of the p-Prl signal peptide
Primary Target IC<sub>50</sub>~ 50 nM inhibiting the processing of the p-Prl signal peptide
Puritysingle spot by TLC
Physicochemical Information
Cell permeableN
Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
421050 0

Documentation

(Z-LL)₂ Ketone - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

(Z-LL)₂ Ketone - Calbiochem Certificates of Analysis

TitleLot Number
421050

References

Přehled odkazů
Weihofen, A., et al. 2002. Science 296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-March-2009 RFH
Synonyms1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
DescriptionA novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
FormOff-white lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₃H₆₄N₆O₉
Peptide SequenceZ-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Puritysingle spot by TLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesWeihofen, A., et al. 2002. Science 296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.