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681725 WY-14643 - CAS 50892-23-4 - Calbiochem

One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands.

WY-14643 - CAS 50892-23-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I

Primary Target: Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
681725
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
50892-23-4C₁₄H₁₄ClN₃O₂S
Description
Overview

This product has been discontinued.



One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
Catalogue Number681725
Brand Family Calbiochem®
Synonyms[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I
References
ReferencesMarx, N., et al. 1999. Circulation 99, 3125.
Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
Dreyer, C., et al. 1992. Cell 68, 879.
Issemann, I., and Green, S. 1990. Nature 347, 645.
Product Information
CAS number50892-23-4
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₄H₁₄ClN₃O₂S
Chemical formulaC₁₄H₁₄ClN₃O₂S
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPeroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAG2915000
Safety Information
R PhraseR: 22-36/37/38-45

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
S PhraseS: 26-36/37/39-45-53

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
681725 0

Documentation

WY-14643 - CAS 50892-23-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

WY-14643 - CAS 50892-23-4 - Calbiochem Certificates of Analysis

TitleLot Number
681725

References

Přehled odkazů
Marx, N., et al. 1999. Circulation 99, 3125.
Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
Dreyer, C., et al. 1992. Cell 68, 879.
Issemann, I., and Green, S. 1990. Nature 347, 645.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
Synonyms[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I
DescriptionA potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
FormWhite crystalline solid
CAS number50892-23-4
RTECSAG2915000
Chemical formulaC₁₄H₁₄ClN₃O₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesMarx, N., et al. 1999. Circulation 99, 3125.
Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
Dreyer, C., et al. 1992. Cell 68, 879.
Issemann, I., and Green, S. 1990. Nature 347, 645.